Protein tyrosine phosphatase 1b deficiency protects against hepatic fibrosis by modulating nadph oxidases
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چکیده
منابع مشابه
Protein tyrosine phosphatase 1B deficiency in podocytes protects against hyperglycemia-induced renal injury
Diabetic nephropathy is one of the most devastating complications of diabetes, and growing evidence implicates podocyte dysfunction in disease pathogenesis. Protein tyrosine phosphatase 1B (PTP1B; encoded by PTPN1) is an established metabolic regulator in vivo but its metabolic functions in podocytes remains unexplored. To that end, we generated podocyte-specific PTP1B knockout (pod-PTP1B KO) m...
متن کاملGene deletion of protein tyrosine phosphatase 1B protects against sepsis-induced cardiovascular dysfunction and mortality.
OBJECTIVE Cardiovascular dysfunction is a major cause of mortality in patients with sepsis. Recently, we showed that gene deletion or pharmacological inhibition of protein tyrosine phosphatase 1B (PTP1B) improves endothelial dysfunction and reduces the severity of experimental heart failure. However, the cardiovascular effect of PTP1B invalidation in sepsis is unknown. Thus, we explored the ben...
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As most intracellular signaling takes place via cascades of phosphorylation and dephosphorylation of tyrosines, protein tyrosine phosphatases have emerged as new and promising targets. Among them, protein tyrosine phosphatase 1B (PTP1B) negatively regulates insulin signaling by dephosphorylation of key tyrosine residues within the regulatory domain of the β-subunit of the insulin receptor, ther...
متن کاملRegulation of growth hormone induced JAK2 and mTOR signalling by hepatic protein tyrosine phosphatase 1B.
Protein tyrosine phosphatase 1B (PTP1B) regulates various signalling pathways including insulin, leptin, IGF-1 and growth hormone (GH) signalling. Transmission of the GH signal depends on Janus kinase 2 (JAK2), which is how PTP1B is thought to modulate GH signalling in the liver, based on studies utilising global PTP1B knockout mice (Ptp1b(-/-)). Here, we investigated the liver-specific role of...
متن کاملOxidative inactivation of protein tyrosine phosphatase 1B by organic hydroperoxides.
Protein tyrosine phosphatases (PTPs) are cysteine-dependent enzymes that play a central role in cell signaling. Organic hydroperoxides cause thiol-reversible, oxidative inactivation of PTP1B in a manner that mirrors the endogenous signaling agent hydrogen peroxide.
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ژورنال
عنوان ژورنال: Redox Biology
سال: 2019
ISSN: 2213-2317
DOI: 10.1016/j.redox.2019.101263